Synthesis and Cytotoxic Activity o f Some Novel Dihyrobenzo [ h ] pyrano [ 3 , 2 - c ] chromene Derivatives 97
نویسندگان
چکیده
Drug Design and Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran *E-mail: [email protected] Received December 9, 2012 DOI 10.1002/jhet.1991 Published online 5 May 2014 in Wiley Online Library (wileyonlinelibrary.com).
منابع مشابه
Synthesis and Cytotoxic Activity of Novel 9-[Hydroxy(Substitutedphenyl) Methyl]-2,2-Dimethyl-2,3,8,9-Tetrahydro-4H,10H-Pyrano [2,3-f ]Chromene-4,10-Diones
Chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. Novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4H,10H-pyrano[2,3-f]chromene-4,10-diones as Glyasperin analogues were synthesized in four steps from known 4-chromone 1. The key step was the preparation of chromane dione 5a by regioselective intramolecular c...
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